AI-Edigene® TFG(E5)-NTRK1(E10) Fusion
CBP20139R
询 价
索取COA
产品描述
产品数据库
| Introduction | |
| Format | RNA |
| Description | TFG(E5)-NTRK1(E10) 融合基因编码一种由TFG蛋白N端与NTRK1蛋白C端（含完整酪氨酸激酶结构域）构成的组成型激活的融合蛋白。其激活机制在于TFG部分的卷曲螺旋结构域介导蛋白发生寡聚化（三聚体或四聚体），无需配体结合即可持续激活NTRK1的激酶活性，从而驱动细胞转化。该融合基因是TRK抑制剂（如拉罗替尼、恩曲替尼）的泛癌种靶向治疗标志物。 |
| Technical Data | |
| Left Gene | TFG |
| Left Breakpoint | chr3:100451516:+ |
| Right Gene | NTRK1 |
| Right Breakpoint | chr1:156844363:+ |
| Cosmic ID | N/A |
| Buffer | RNase-free H2O |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purity | Download for COA |
| RNA electrophoresis | Download for COA |
| Sanger sequencing |  |
| Storage | -90~ -70℃ |
| Expiry | 12 months from the date of manufacture |
